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Everyone has a donor: contribution of the Chinese experience to global practice of haploidentical hematopoieticstem cell transplantation

Meng Lv, Yingjun Chang, Xiaojun Huang

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 45-56 doi: 10.1007/s11684-017-0595-7

Abstract: Human leukocyte antigen (HLA)-matched donors for hematopoietic stem cell transplantation (HSCT) haveChinese approach have been greatly improved by implementing new individualized conditioning regimens, donorHaplo-HSCT has exhibited similar efficacy to HLA-matched HSCT and has gradually become the predominant donorsource and the first alternative donor choice for allo-HSCT in China.This review will focus on how the new era in which “everyone has a donor” will become a reality in China

Keywords： haploidentical hematopoietic stem cell transplantation     conditioning     graft-versus-host disease     relapse     infection     donor selection    

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leukemia/myelodysplastic syndrome with unsatisfactory response to minimal residual disease-directed donorlymphocyte infusion after allogeneic hematopoietic stem cell transplantation

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 238-249 doi: 10.1007/s11684-017-0599-3

Abstract: was investigated in patients with unsatisfactory response to minimal residual disease (MRD)-directed donorDLI and could be a potential salvage treatment for these patients after allogeneic hematopoietic stem cell

Keywords： interferon-α     hematopoietic stem cell transplantation     minimal residual disease     donor lymphocyte infusion    

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used as a salvage option for patients with relapsed acute leukemia post-chemotherapy plus modified donor

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 728-739 doi: 10.1007/s11684-021-0833-x

Abstract: Relapse is the main problem after allogeneic hematopoietic stem cell transplantation (allo-HSCT).efficacy of HSCT2 in patients with relapsed/refractory acute leukemia (AL) post-chemotherapy plus modified donor

Keywords： second hematopoietic stem cell transplantation     acute leukemia     relapse     chemotherapy     modified donor    

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Advancement of human leukocyte antigen-partially matched related hematopoietic stem cell transplantation

Xiaodong Mo, Xiaojun Huang

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 306-315 doi: 10.1007/s11684-013-0279-x

Abstract:

Allogeneic hematopoietic stem cell transplantation (HSCT) is one of the most effective options forSeveral protocols (with or without ex vivo T-cell depletion (TCD)) have been established worldwide

Keywords： partially matched related donor     hematopoietic stem cell transplantation     allogeneic    

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Donor-Derived CD19-Targeted T Cell Infusion Eliminates B Cell Acute Lymphoblastic Leukemia Minimal ResidualDisease with No Response to Donor Lymphocytes after Allogeneic Hematopoietic Stem Cell Transplantation Article

Yifei Cheng,Yuhong Chen,Chenhua Yan,Yu Wang,Xiangyu Zhao,Yao Chen,Wei Han,Lanping Xu,Xiaohui Zhang,Kaiyan Liu,Shasha Wang,Lungji Chang,Lei Xiao,Xiaojun Huang

Engineering 2019, Volume 5, Issue 1,   Pages 150-155 doi: 10.1016/j.eng.2018.12.006

Abstract: Leukemia relapse is still the leading cause of treatment failure after allogeneic hematopoietic stem celltransplantation (allo-HSCT) for B cell acute lymphoblastic leukemia (B-ALL).Donor lymphoblastic infusion (DLI) is the main established approach to treat B-ALL with MRD after allo-HSCTAlthough donor-derived cluster of differentiation (CD)19-directed chimeric antigen receptor-modifiedDonor-derived CAR T cell infusions seem to be an effective and safe intervention for patients with MRD

Keywords： Donor-derived CD19-targeted T cell infusion     Hematopoietic stem cell transplantation     B cell acute lymphoblastic    

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patients receiving haploidentical allografts and those receiving human leukocyte antigen-matched sibling donor

Xuying Pei, Xiangyu Zhao, Yu Wang, Lanping Xu, Xiaohui Zhang, Kaiyan Liu, Yingjun Chang, Xiaojun Huang

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 153-163 doi: 10.1007/s11684-017-0548-1

Abstract:

To establish optimal reference values for recovered immune cell subsets, we prospectively investigatedpost-transplant immune reconstitution (IR) in 144 patients who received allogeneic stem cell transplantationImmune recovery was generally faster under HLA-matched sibling donor transplantation than under haploidenticaldisplay superior survival, and the levels of recovery in immune cells need not reach those in healthy donorthat data from this recipient cohort should be used as reference values for post-transplant immune cell

Keywords： immune reconstitution     hematopoietic stem cell transplantation     event-free patients     reference range    

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The influence of brain death on donor liver and the potential mechanisms of protective intervention

Shui-Jun ZHANG, Tao WANG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 8-14 doi: 10.1007/s11684-011-0109-y

Abstract: The quality of donor organs is closely related to the outcome of the transplantation.conducted in the past 10 years have shown that brain death is associated with effects on the decreased donorHowever, whether the decrease in the viability of donor organs is caused by brain death or by the eventsintroduce the advances and controversies regarding the influence of brain death on the viability of donorlivers and to summarize the mechanisms of the different protective interventions for donor livers.

Keywords： brain death     donor liver    

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Regulation of radicals by hydrogen-donor solvent in direct coal liquefaction

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 12,   Pages 1689-1699 doi: 10.1007/s11705-022-2186-7

Abstract: reaction between the formation and annihilation of coal radical fragments and the effect of hydrogen-donorshowed that the adjustment of the coal radical fragments could be made by the addition of hydrogen-donorThe synergistic mechanism of hydrogen supply and hydrogenolysis of hydrogen-donor solvent was proposed

Keywords： direct coal liquefaction     hydrogen-donor solvent     induced pyrolysis     radical mechanism     density functional    

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Factors influencing the somatic cell nuclear transfer efficiency in pigs

Yong JIN, Manling ZHANG, Xinrong JU, Shuang LIANG, Qiang XIONG, Lihua ZHAO, Xiaowei NIE, Daorong HOU, Qiang LIU, Junzheng WANG, Chenyu WANG, Xiaokang LI, Lining ZHANG, Xiaorui LIU, Ying WANG, Haiyuan YANG, Yifan DAI, Rongfeng LI

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 73-80 doi: 10.15302/J-FASE-2018220

Abstract: The results demonstrated that cells at high confluence (>90%) used as donor cell resulted in higherThe number of blastocysts transferred by somatic cell nuclear transfer (SCNT) did not significantly affectfrom culture 5 d after SCNT achieved a significantly higher pregnancy rate compared with one to two celldelivery rate and the largest litter size were obtained when Bama Miniature pig fibroblasts were used as donor

Keywords： blastocyst     donor cell     estrus synchronization     pregnancy rate     pig cloning     somatic cell nuclear transfer    

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Enhanced photoelectrochemical water splitting with a donor-acceptor polyimide

Frontiers in Energy doi: 10.1007/s11708-023-0910-8

Abstract: owing to its distinct advantages of high visible-light response, facile synthesis, molecularly tunable donor-acceptorsimple spin-coating method was reported, and their PEC properties were investigated using melamine as donor

Keywords： polyimide (PI) film     photoelectrochemistry     band structure engineering     aromatic unit    

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disease-directed immunotherapy for high-risk myelodysplastic syndrome after allogeneic hematopoietic stem cell

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 354-364 doi: 10.1007/s11684-018-0665-5

Abstract: including interferon- (IFN- ) treatment and chemotherapy plus granulocyte colony-stimulating factor-primed donorhigh-risk myelodysplastic syndrome (MDS) who were MRD-positive after allogeneic hematopoietic stem cellHigh-risk MDS patients who received non-T-cell-depleted allo-HSCT at the Peking University Institute

Keywords： donor leukocyte infusion     hematopoietic stem cell transplantation     interferon-   

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Partial liver transplantation

Nianqiao GONG, Xiaoping CHEN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 1-7 doi: 10.1007/s11684-010-0105-7

Abstract: transplantation, including reduced-size liver transplantation, split liver transplantation, and living donorliver transplantation, has been developed with several innovative techniques because of donor shortageanatomical classification, benefiting children and small adult recipients but failing to relieve the overall donorThe first and most important issue involving living donor liver transplantation is donor safety.Before surgery, a series of donor evaluations—including anatomical, liver volume, and liver function

Keywords： partial liver transplantation     reduced-size liver transplantation     split liver transplantation     living donor    

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Acid Orange 7 degradation using methane as the sole carbon source and electron donor

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 3, doi: 10.1007/s11783-021-1468-5

Abstract:

• AO7 degradation was coupled with anaerobic methane oxidation.

Keywords： Azo dyes     AO7 degradation     Anaerobic methane oxidation     Microbial community     ANME-2d    

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Machine Perfusion Plus for Extended Criteria Donor Liver Grafts: Making Every Liver Count Review

Zhoucheng Wang, Jack Martin, Jiongjie Yu, Kai Wang, Kourosh Saeb-Parsy, Xiao Xu

Engineering 2024, Volume 32, Issue 1,   Pages 30-41 doi: 10.1016/j.eng.2023.11.003

Abstract: the most effective treatment for end-stage liver diseases but is limited by the shortage of healthy donorExtended criteria donor (ECD) liver grafts are increasingly utilized in clinical practice to mitigate

Keywords： Liver transplantation     Extended criteria donor     Machine perfusion plus     Organ shortage    

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Reducing biliary complications in adult-to-adult living donor liver transplantation using right lobe

YAN Lunan, WEN Tianfu, WANG Wentao, YANG Jiayin, XU Mingqing, CHEN Zheyu, WU Hong

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 130-133 doi: 10.1007/s11684-008-0024-z

Abstract: experience of using right lobe liver grafts to reduce biliary complications in adult-to-adult (A-A) living donorFrom January 2002 to October 2007, 124 adult patients underwent living donor liver transplantation usingBiliary reconstruction for 178 hepatic duct orifices from 124 donor grafts was performed which included

Keywords： microsurgical     October     improved     success     transplantation    

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Title Author Date Type Operation

Everyone has a donor: contribution of the Chinese experience to global practice of haploidentical hematopoieticstem cell transplantation

Meng Lv, Yingjun Chang, Xiaojun Huang

Journal Article

leukemia/myelodysplastic syndrome with unsatisfactory response to minimal residual disease-directed donorlymphocyte infusion after allogeneic hematopoietic stem cell transplantation

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Journal Article

used as a salvage option for patients with relapsed acute leukemia post-chemotherapy plus modified donor

Journal Article

Advancement of human leukocyte antigen-partially matched related hematopoietic stem cell transplantation

Xiaodong Mo, Xiaojun Huang

Journal Article

Donor-Derived CD19-Targeted T Cell Infusion Eliminates B Cell Acute Lymphoblastic Leukemia Minimal ResidualDisease with No Response to Donor Lymphocytes after Allogeneic Hematopoietic Stem Cell Transplantation

Yifei Cheng,Yuhong Chen,Chenhua Yan,Yu Wang,Xiangyu Zhao,Yao Chen,Wei Han,Lanping Xu,Xiaohui Zhang,Kaiyan Liu,Shasha Wang,Lungji Chang,Lei Xiao,Xiaojun Huang

Journal Article

patients receiving haploidentical allografts and those receiving human leukocyte antigen-matched sibling donor

Xuying Pei, Xiangyu Zhao, Yu Wang, Lanping Xu, Xiaohui Zhang, Kaiyan Liu, Yingjun Chang, Xiaojun Huang

Journal Article

The influence of brain death on donor liver and the potential mechanisms of protective intervention

Shui-Jun ZHANG, Tao WANG

Journal Article

Regulation of radicals by hydrogen-donor solvent in direct coal liquefaction

Journal Article

Factors influencing the somatic cell nuclear transfer efficiency in pigs

Yong JIN, Manling ZHANG, Xinrong JU, Shuang LIANG, Qiang XIONG, Lihua ZHAO, Xiaowei NIE, Daorong HOU, Qiang LIU, Junzheng WANG, Chenyu WANG, Xiaokang LI, Lining ZHANG, Xiaorui LIU, Ying WANG, Haiyuan YANG, Yifan DAI, Rongfeng LI

Journal Article

Enhanced photoelectrochemical water splitting with a donor-acceptor polyimide

Journal Article

disease-directed immunotherapy for high-risk myelodysplastic syndrome after allogeneic hematopoietic stem cell

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Journal Article

Partial liver transplantation

Nianqiao GONG, Xiaoping CHEN

Journal Article

Acid Orange 7 degradation using methane as the sole carbon source and electron donor

Journal Article

Machine Perfusion Plus for Extended Criteria Donor Liver Grafts: Making Every Liver Count

Zhoucheng Wang, Jack Martin, Jiongjie Yu, Kai Wang, Kourosh Saeb-Parsy, Xiao Xu

Journal Article

Reducing biliary complications in adult-to-adult living donor liver transplantation using right lobe

YAN Lunan, WEN Tianfu, WANG Wentao, YANG Jiayin, XU Mingqing, CHEN Zheyu, WU Hong

Journal Article